You'll still miss out on the bottom end with a bigger subwoofer unless you have a properly designed IB. So no matter what subwoofer you have short of an IB or a Thigpen Rotary sub, you'll be stuck with a compromised solution. Multiple smaller subwoofers are simply more cost effective in the long run (IMO) because they generally offer better bass uniformity when set up correctly and many dual subwoofers options can outgun a bigger sub within their limits. So dynamically you have a more potent solution for the same money within 85-90% of the bass range.
Concerning resonances, the bigger sub with a deeper response can also energize room modes easier which may result in a worse response in your room. So again, do you buy a bigger sub to get that extra 5-10 Hz extension, or better linearity higher up with a smoother bass response ? As for buying used vs new, well, if you buy new then you have a warranty. If you buy used then anything goes, whether it was a better deal or not.